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In several studies, no significant modifications of specific CYP isozyme expression patterns were observed in the liver of subjects aged between 12 and 73 years (102, 127, 128)
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In an open-label RCT ( n = 96), oral administration of melatonin tablets (3 mg/d, 1 h before sleep, for 7 days) with standard treatment, substantially improved sleep quality and blood O 2 saturation parameters in hospitalized COVID-19 patients 667
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