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Here is how PrEP works: When CD4 cells are infected with HIV, they become little factories that make thousands of new copies of this virus each day HIV drugs work by blocking HIV from making copies of itself If an HIV-negative woman already has HIV drugs in her bloodstream when she is exposed to HIV, for example during sex without a condom, the medicine can keep the virus from making copies of itself and prevent her from acquiring HIV Click above to view or download this fact sheet as a PDF slide presentation Daily Oral PrEP In July 2012, the US Food and Drug Administration (FDA) approved the daily use of Truvada (tenofovir disoproxil fumarate plus emtricitabine, or TDF/FTC), an oral (by mouth) medication, as PrEP for sexually active adults vulnerable to acquiring HIV