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By using high-resolution 1H magnetic resonance spectroscopy (MRS), TNBC with high GLS activity exhibits low cellular glutamine pool size (glutamine concentration), which significantly increases after the inhibition of GLS 120
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Studies have shown that using antagonists of distinct iGluRs is effective because they exert anti-proliferative actions, inhibit migration, and alter the morphology of tumor cells, and that they have synergistic effects when used with chemotherapy agents, such as cisplatin or cyclophosphamide (127)
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