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This creates a “whack-a-mole” scenario, where pain shifts to different areas, often outpacing the relief provided by steroid injections, which are limited to treating one or two specific locations at a time
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Others proteins related to the antioxidant defense (catalase, superoxide dismutase [Mn], thioredoxin 1, GSH reductase) and nicotinamide adenine dinucleotide phosphate (NADPH) regeneration through the oxidative pentose phosphate pathway (glucose‐6‐phosphate 1‐dehydrogenase, 6‐phosphogluconate dehydrogenase) have been measured as differentially expressed in the BSO‐treated cells, but with a lower logFC magnitude (Tonelli, Chio, & Tuveson, 2018
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