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The above procedure was repeated with inhibitor concentrations spanning 0.3-60 μM to determine the effective concentration (EC50) required to inhibit 50% NNMT activity in cultured adipocytes
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A large patient-level meta-analysis showed that estimated glomerular filtration rate (eGFR) decline and albuminuria are both associated with increased risk of adverse CV and renal events in the general population 78
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