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A total of 47 combinations in 44 pre-clinical studies from 2016 to 2021 were retrieved from PubMed using search terms (vitamin c OR ascorbate OR ascorbic acid) AND (combination OR synergy OR combined) AND (cancer) Tx treatment, mM millimolar, IP intraperitoneal, IV intravenous, JQ1 Thieno-triazolo-1,4-diazepine, 5-FU 5-fluorouracil, Vit vitamin, IR irradiation, TMZ temozolomide, Gem gemcitabine, Dox Doxycycline, Oxa oxaplatin, TETA Triethylenetetramine, BRAF v-raf murine sarcoma viral oncogene homolog B1, PARP poly (ADP-ribose) polymerase, d-TPP TPP derivative dodecyl-TPP, ATO arsenic trioxide, 3-PO 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one, CLL chronic lymphocytic leukemia, AML acute myeloid leukemia, APL acute promyelocytic leukemia, ALL acute lymphoblastic leukemia, TET ten eleven translocation Pre-clinical combination studies A comprehensive overview of all 71 retrieved studies from 1989 to 2021 (Fig

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Sodium dodecyl sulfate and phosphate buffer solution were used as a positive and negative control, respectively