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[191] observed that although the administration of HRS does not significantly alter the levels of MPO, MDA, IL‐6, and TNF‐α in intestinal I/R rats, it results in reduced tissue damage and apoptosis

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In conclusion, non-pharmacological therapies that focus on controlling the etiology of liver disease, improving nutrition, increasing muscle mass, mitigating triggers and risk factors, and enhancing coping mechanisms are significantly more effective in combating fatigue in cirrhosis compared to pharmacological treatments (Figure 2) (4, 9)