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doi: 10.3389/fcimb.2022.953962 200 ZhuY.JiangH.ChenZ.LuB.LiJ.ShenX.et al
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From a mechanistic point of view, metformin can reduce histone acetylation at the CCR8 promoter and inhibit CCR8 expression on tumor-infiltrating Treg cells by upregulating AMPK-activated Sirtuin 2 (SIRT2), thus enhancing the effectiveness of anti-PD-1 immunotherapy (73)
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