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At the same time, the production of cytokines and chemokines such as IL12, IL23, IL1β, IL6, TNFα, TGFβ, CXCL1, and CCL2 can result in T cell recruitment and polarization towards proinflammatory phenotypes [49,50]
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In dendritic cells, increased cholesterol levels impair tumor antigen presentation, while in lymphocytes, excess cholesterol favors the development of a Treg phenotype and prevents the release of antitumor cytokines, further weakening the immune response against tumors
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