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Various human studies have observed an association of a decrease in lung function with higher incidences of deficiency and insufficiency in circulating levels of 25(OH)VD and that of alpha-1-antitrypsin [101,102]
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The increased oxidative stress seems to be the second “hit” in the progression from NAFL to NASH: the increase in ROS and consequently in lipid peroxidation has been associated to hepatocellular damage, inflammation, and eventual fibrosis due to the activation of hepatic stellate cells
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