glutathione and excision repair Reduced expression of OXPHOS DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes: the PROLONG study Hap1 cells

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In addition, the inflammasome senses stress and cell damage, such as high ATP concentrations, mitochondrial-derived components (cardiolipin, ROS, mitochondrial DNA (mtDNA)), ER stress, intracellular calcium influx, uric acid, serum amyloid A, and cholesterol crystals ( Inflammasome activation in IBD Inflammasome activation in the intestinal mucosa promotes pathogen clearance and Mø-mediated epithelial barrier recovery, with NLRP3 expressed both in colonic epithelial cells and Mø ( NLRP3 , Caspase-1 , NIMA-related kinase 7 ( NEK7 ), and GSDMD expression were observed in inflamed versus non-inflamed tissue of UC patients ( NLRP3, NLRC4, NLRP12 , and IL-10 , correlated with higher gene transcription in severe compared to mild UC patients ( Furthermore, intestinal barrier dysfunction in DSS-induced colitis in mice allows the translocation of bacteria to stimulate lamina propria Mø via TLR/NF-κB, leading to pro-IL-1β and pro-IL-18 transcription, consequently NLRP3 activation ( in vitro , producing high IL-1β levels in a caspase-1-, NLRP3- and ASC-dependent manner ( Nlrp3 and Caspase 1 genes was observed in IBD models, reporting in nlrp3 -null mice less severe colitis and lower colonic pro-inflammatory cytokine production ( Additionally, the inflammasome is essential for protection against colitis-associated dysplasia and tumorigenesis towards colorectal cancer (CRC) ( Nlrp3- and Caspase 1 -null mice treated with AOM (azoxymethane)/DSS develop large tumors with significant hyperplasia, and inflammation, with reduced production of IL-18 and the presence of proliferating dysplastic cells in dysplasia regions

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Distribution of eukaryotic serine racemases in the bacterial domain and characterization of a representative protein in Roseobacter litoralis Och 149