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further proposed four immune subtypes: Cold tumors (no lymphocyte infiltration within the tumor and at the tumor border), immune excluded tumors (little lymphocyte infiltration at the tumor border), immunosuppressive tumors (little T cell and cytotoxic T cell infiltration within the tumor), and hot tumors (high levels of T cell and cytotoxic T cell infiltration within the tumor) (152)

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Further studies in Drosophila , nematodes, and mice have confirmed the conserved role of inhibiting the insulin/insulin-like growth factor-1 signaling (IIS) pathway in prolonging lifespan