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While no significant changes were observed in free testosterone or SHBG levels, treatment with GLP-1 RAs was associated with a significant rise in bioavailable testosterone and a notable reduction in HbA1c, indicating potential dual metabolic and endocrine benefits
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In contrast, another randomized, controlled trial of adjunctive minocycline and celecoxib to treat bipolar depression in a 2 × 2 factorial design found no significant differences between the groups (minocycline plus celecoxib, minocycline plus placebo, placebo plus celecoxib, and placebo plus placebo) (Husain et al., 2020)
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