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Dihexa (also known as PNB-0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the blood–brain barrier and has shown synaptogenic effects in preclinical models. The often-quoted
Overexpression of efflux genes, often on plasmids or via mutations, is common in resistant strains
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The delta sleep-inducing peptide inhibits CRH at the hypothalamic level, reducing the signal that drives ACTH release and, downstream, cortisol secretion from the adrenal glands
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