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FIGURE 1 Quercetin’s glycosides (e.g., rutin, isoquercitrin) are more water-soluble, but once ingested, they undergo de-glycosylation and rapid phase II metabolism (glucuronidation, sulfation, methylation), yielding metabolites (e.g., quercetin-3′-O-glucuronide) with different bioactivities and kinetics
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