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The functional annotation of peak-associated genes was performed using the R interface ( for GREAT 69 , the whole genome as a background and the “basal plus extension” gene association rule with the following parameters: adv_upstream = 5.0kb, adv_downstream = 1.0 kb, adv_span = 100 kb, MSigDB (Broad Institute) was used as a source of reference for functional gene sets
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